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The Michaelis-Menten constant for an enzyme-catalysed reaction is referred to as ${K_m}$, and the maximum velocity of such a reaction is known as ${V_{\max }}$.

Which statement about ${K_m}$ and ${V_{\max }}$ is correct?

1 ) 

An enzyme with a high value of ${K_m}$ can reach its ${V_{\max }}$ at a low substrate concentration.  

2 ) 

An enzyme with a high value of ${K_m}$ has a high affinity to its substrate. 

3 ) 

An enzyme with a low value of ${K_m}$ can reach its ${V_{\max }}$ at a high substrate concentration.  

4 ) 

An enzyme with a low value of ${K_m}$ has a high affinity to its substrate. 

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