The partial pressure of oxygen in blood vessels in different parts of the body affects the percentage saturation of each haemoglobin molecule with oxygen.
Which statement explains the difference in saturation between a resting and an active muscle?

1 )
A small decrease in partial pressure causes two atoms of oxygen to leave each haemoglobin molecule because the oxygen dissociation curve is sigmoid shaped.
A small decrease in partial pressure between 4 kPa and 7 kPa causes two molecules of oxygen to leave each haemoglobin molecule because the oxygen dissociation curve is steep.
3 )
Loading of oxygen is slower between 4 kPa and 7 kPa due to binding of one oxygen molecule to each haemoglobin molecule making the next one harder to bind.
4 )
Loading of oxygen is faster between 4 kPa and 7kPa due to binding of one oxygen molecule to each haemoglobin molecule making the next one easier to bind.
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