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Which statement about the effect of substrate concentration on the activity of an enzyme is correct?

1 ) 

Above a certain concentration of substrate an enzyme reaches its maximum rate of reaction.

2 ) 

At high concentration of competitive inhibitor increasing the substrate concentration has no effect.

3 ) 

At high substrate concentration a non-competitive inhibitor no longer affects the enzyme activity.

4 ) 

The higher the concentration of substrate the faster an enzyme can catalyse a reaction.

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