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Which statement is true for the Bohr effect?

1 ) 

As the partial pressure of carbon dioxide increases the dissociation curve becomes S- shaped (sigmoid).

2 ) 

At higher partial pressures of carbon dioxide and equal partial pressures of oxygen, the percentage saturation of haemoglobin with oxygen will be higher.

3 ) 

The carbon dioxide in the air prevents haemoglobin becoming fully saturated with oxygen during gas exchange in the lungs.

4 ) 

The release of oxygen from haemoglobin is more likely at higher partial pressures of carbon dioxide.

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