Muscle cells have cell surface receptors for the neurotransmitter, ACh. These receptors allow the muscle to respond to a nerve impulse.
In the condition myasthenia gravis, the helper T cells stimulate a clone of B cells to become plasma cells and secrete antibodies that bind to and block these ACh receptors. The muscles cannot be stimulated and begin to break down.
A short-term treatment for myasthenia gravis is to inject monoclonal antibodies into the blood.
What is the target of these monoclonal antibodies?
antibodies that bind to ACh receptors
2 )
muscle cell surface ACh receptors
3 )
plasma cells secreting anti-ACh receptor antibodies
4 )
the stimulating neurotransmitter ACh
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