Strains of Mycobacterium have been found that are:
• multiple drug-resistant (MDR) – resistant to the drugs most commonly used to control tuberculosis (TB)
• extensively drug-resistant (XDR) – resistant to the drugs most commonly used to control TB and to some of the drugs less commonly used to control TB
• totally drug-resistant (TDR) – resistant to all known drugs used to control TB.
Comparisons of some of these strains of Mycobacterium found differences in the thickness of their cell walls, as shown in the table.
What conclusions may be drawn from this information?
1 )
Bacteria secrete thicker cell walls when in contact with a mixture of drugs.
2 )
The cell walls of TDR bacteria are impermeable to drugs.
Thicker cell walls may form a physical barrier to drugs.
4 )
XDR bacteria have cell walls between 17 and 20nm thick.
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