A mutation occurred within the DNA sequence coding for an enzyme, causing a decrease in the rate of a reaction catalysed by this enzyme.
Which statements could explain the decrease in the rate of reaction?
1 An inhibitor for this enzyme has an increased affinity for the enzyme and forms an enzyme–inhibitor complex more easily.
2 The active site of the enzyme might have changed shape and so is no longer complementary.
3 The activation energy for the reaction with the mutated enzyme is greater than with the non-mutated enzyme.
1 )
1, 2 and 3
2 )
1 and 2 only
1 and 3 only
4 )
2 and 3 only
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