Sickle cell anaemia is caused by a mutation in an allele of the gene that codes for the $\beta $-globin polypeptide of haemoglobin.
The diagram shows the sequence of bases in a small section of the coding strand of DNA for
both the $H{b^A}$ (normal) and $H{b^S}$ (sickle cell) $\beta $-globin alleles.
$H{b^A}{\text{ }}CTGACTCCTGAGGAGAAGTCT$
$H{b^S}{\text{ }}CTGACTCCTGTGGAGAAGTCT$
How will the mutation in the allele result in the production of an altered version of the $\beta $-globin polypeptide?
A tRNA molecule with the anticodon GUG will hydrogen bond to the altered codon on mRNA.
2 )
All the amino acids coded for after the mutation will differ from those in the $H{b^A}$ protein.
3 )
mRNA transcribed from the $H{b^S}$ allele will contain the codon CAC instead of the codon CTC.
4 )
The ribosome will be unable to continue translation of the $H{b^S}$ mRNA after the altered codon.
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