9700/11 Biology Oct Nov 2012 Online Test | Cambridge AS and A Level MCQ

Some inhibitors of enzyme reactions bind to the enzyme/ substrate complex.
Which statements about this type of inhibition are correct?
1 The active site changes shape.
2 The inhibitor is non-competitive.
3 The initial rate of reaction is reduced.
4 The maximum rate of reaction $\left( {{V_{max}}} \right)$ is increased.