The sequence of bases in mRNA for the first eight amino acids in the β-polypeptide of adult haemoglobin is:
GUG–CAC–CUG–ACU–CCU–GAG–GAG–AAG.
In haemoglobin C, which is a cause of haemolytic anaemia, the sequence is:
GUG–CAC–CUG–ACU–CCU–AAG–GAG–AAG.
The coding for seven of the amino acids is listed.
Which change occurs to the amino acid sequence of adult haemoglobin to make haemoglobin C?
1 )
Histidine is changed to leucine.
2 )
Proline is changed to threonine.
Glutamic acid is changed to lysine.
4 )
Leucine is changed to phenylalanine.
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