Red blood cells may contain a molecule known as 2,3-bisphosphoglycerate (2,3-BPG).
When 2,3-BPG binds to haemoglobin, a higher partial pressure of oxygen is needed to bring about 50% saturation of haemoglobin with oxygen.
Which statements about the effect of 2,3-BPG are correct?
1- 2,3-BPG in red blood cells causes the oxygen dissociation curve to shift to the right.
2- The binding of 2,3-BPG to haemoglobin reduces the Bohr effect.
3- The binding of 2,3-BPG to haemoglobin lowers the affinity of the haemoglobin for oxygen.
4- When 2,3-BPG is not present, oxyhaemoglobin is less likely to unload oxygen.
1 )
1 and 2
1 and 3
3 )
2 and 3
4 )
3 and 4
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