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Which description of cell surface membrane permeability is correct?

1 ) 

An increase in the concentration of cholesterol molecules in the cell surface membrane can increase its permeability to hydrophilic substances.

2 ) 

Cell surface membrane permeability to large hydrophilic molecules is high and can be increased by membrane transport proteins involved in facilitated diffusion.

3 ) 

The permeability of the cell surface membrane to ions increases as the proportion of saturated fatty acid chains in the phospholipids increases.

4 ) 

Without the presence of carrier and channel membrane proteins, the cell surface membrane has a low permeability to large polar molecules.

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