Red blood cells may contain a molecule known as 2,3-bisphophoglycerate (2,3BPG). When 2,3BPG binds to haemoglobin a higher partial pressure of oxygen is needed to bring about 50% saturation of haemoglobin with oxygen.
Which statements about the effect of 2,3BPG are correct?
1 2,3BPG in red blood cells causes the oxygen dissociation curve to shift to the left.
2 The binding of 2,3BPG to haemoglobin lowers the affinity of the haemoglobin for oxygen.
3 Binding of 2,3BPG to haemoglobin reduces the Bohr effect.
4 When 2,3BPG is absent, oxyhaemoglobin is less likely to unload oxygen.
1 )
1 and 3
2 )
2 and 4
3 )
1 only
2 only
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