The photomicrographs show an artery from a non-smoker and a smoker.
What is the reason that the smoker’s artery looks like this?

1 )
A cancerous tumour has formed and is blocking the lumen.
Nicotine has damaged the artery endothelium causing a plaque.
3 )
Tar has stuck to the artery wall forming a blockage.
4 )
The artery has become constricted due to carbon monoxide.
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