Sickle cell anaemia is caused by a mutation in an allele of the gene that codes for the $\beta $-globin polypeptide of haemoglobin.
The diagram shows the sequence of bases in a small section of the coding strand of DNA for both the HbA (normal) and HbS (sickle cell) $\beta $-globin alleles.
HbA CTGACTCCTGAGGAGAAGTCT
HbS CTGACTCCTGTGGAGAAGTCT
How will the mutation in the HbS allele result in the production of an altered version of the $\beta $-globin polypeptide?
A tRNA molecule with the anticodon GUG will hydrogen bond to the altered codon on mRNA.
2 )
All the amino acids coded for after the mutation will differ from those in the HbA protein.
3 )
mRNA transcribed from the HbS allele will contain the codon CAC instead of the codon CTC.
4 )
The ribosome will be unable to continue translation of the HbS mRNA after the altered codon.
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